GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs1552244 | 1 | rs6807846 | chr3:10134491 | C3orf10 | chr3:10157333-10168873:+ | -0.2 | -4.37 | 1.56E-5 | Alzheimer's disease |
| THCA | cis | rs1552244 | 1 | rs6807846 | chr3:10134491 | VHL | chr3:10183319-10193744:+ | -0.19 | -4.45 | 1.08E-5 | Alzheimer's disease |
| THCA | cis | rs12107539 | 1 | rs6808091 | chr3:151073997 | GPR87 | chr3:151011876-151034636:- | 0.19 | 4.29 | 2.14E-5 | Lung function (forced expiratory flow between 25% and 75% of forced vital capacity) |
| THCA | cis | rs12107539 | 1 | rs6808091 | chr3:151073997 | P2RY14 | chr3:150929905-150996230:- | -0.19 | -4.1 | 4.86E-5 | Lung function (forced expiratory flow between 25% and 75% of forced vital capacity) |
| THCA | cis | rs1031925 | 1 | rs6809155 | chr3:51623216 | TEX264 | chr3:51705222-51738338:+ | -0.22 | -5.72 | 1.9E-8 | Melanoma |
| THCA | cis | rs73201462 | 1 | rs6810006 | chr3:127856058 | EEFSEC | chr3:127872313-128127488:+ | -0.27 | -4.69 | 3.52E-6 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio |
| THCA | cis | rs9876781 | 1 | rs6810060 | chr3:48434748 | ATRIP | chr3:48488141-48507708:+ | 0.17 | 3.78 | 0.000176 | Longevity |
| THCA | cis | rs9876781 | 1 | rs6810060 | chr3:48434748 | TREX1 | chr3:48501186-48509043:+ | -0.24 | -5.66 | 2.59E-8 | Longevity |
| THCA | cis | rs7692995 | 1 | rs6810665 | chr4:17984462 | DCAF16 | chr4:17802280-17812381:- | -0.2 | -4.39 | 1.41E-5 | Height |
| THCA | cis | rs7665090 | 1 | rs6810869 | chr4:103558514 | CISD2 | chr4:103790135-103809913:+ | -0.16 | -3.62 | 0.000321 | Primary biliary cirrhosis |
| THCA | cis | rs7665090 | 1 | rs6810869 | chr4:103558514 | NFKB1 | chr4:103422486-103538458:+ | 0.15 | 4.2 | 3.16E-5 | Primary biliary cirrhosis |
| THCA | cis | rs6832769 | 1 | rs6811520 | chr4:56315178 | TMEM165 | chr4:56262090-56292342:+ | -0.15 | -3.6 | 0.000351 | Personality dimensions |
| THCA | cis | rs7692995 | 1 | rs6811842 | chr4:18009798 | DCAF16 | chr4:17802280-17812381:- | -0.2 | -4.48 | 9.24E-6 | Height |
| THCA | cis | rs6832769 | 1 | rs6812042 | chr4:56396079 | TMEM165 | chr4:56262090-56292342:+ | -0.15 | -3.71 | 0.000234 | Personality dimensions |
| THCA | cis | rs8020441 | 1 | rs68120925 | chr14:51169258 | SAV1 | chr14:51100360-51135023:- | 0.31 | 6.33 | 5.71E-10 | Cognitive performance |